Extramedullary Clonal Hematopoiesis with Indeterminate Potential
نویسندگان
چکیده
منابع مشابه
Copy number alterations detected as clonal hematopoiesis of indeterminate potential.
Recent studies have revealed that clonal hematopoiesis of indeterminate potential (CHIP) is an important risk factor for therapy-related myeloid neoplasms (t-MNs). CHIP is currently defined as a clonal hematopoietic population carrying somatic point mutations in 1 of the leukemia-associated genes. Patients with t-MNs often present with chromosomal abnormalities in addition to somatic point muta...
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Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human aging. Clonally restricted hematopoiesis is associated with an increased risk of subsequent diagnosis of myeloid or lymphoid neoplasia and increased all-cause mortality. Although myelodysplastic syndromes (MDS) are defined by cyt...
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Department of Medical Oncology, Division of Hematological Malignancies, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, MA; Division of Hematology-Oncology, Moores Cancer Center at the University of California at San Diego, La Jolla, CA; Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA; Department of Hematologic Oncology and Blood D...
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topic hematopoiesis that is a common feature of chronic bone marrow failure. However, EMH is rarely encountered in general radiological practice (1). A mass-like EMH lesion in the liver is an atypical presentation. Furthermore, hepatic periportal EMH is less common than other types of focal hepatic EMH (2). We present the sonographic and CT findings of a histologically confirmed case of hepatic...
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A 77-year-old woman with multiple myeloma for 5 years presented with obtundation, drowsiness, and disorientation over 15 days. Complete blood count revealed thrombocytopenia (25,000/µL). A brain CT disclosed multiple extraaxial hyperdense foci without bone destruction. Differential diagnosis included tumors (meningiomas, leukemia), subdural hematomas, and intracranial hemorrhages; the lesion's ...
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ژورنال
عنوان ژورنال: Clinical Lymphoma Myeloma and Leukemia
سال: 2021
ISSN: 2152-2650
DOI: 10.1016/j.clml.2021.04.008